biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
51 kDa
species reactivity
rabbit, bovine, guinea pig, mouse, rat, horse, dog, human
concentration
0.5 mg - 1 mg/mL
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BACE1(23621)
General description
β-位点APP裂解酶(BACE-1)被称为β-分泌酶。它由N端信号肽(SP)、前肽(Pro)结构域、催化结构域、跨膜结构域和C端尾部组成。
BACE1是肽酶A1蛋白家族的成员,是主要在高尔基体中发现的I型整合膜糖蛋白和天冬氨酸蛋白酶。
Immunogen
靶向人BACE1的N端区域的合成肽
Biochem/physiol Actions
β位点APP裂解酶(BACE-1)作为淀粉样蛋白-β-肽(Aβ)的限速酶。BACE-1的过表达导致β-分泌酶活性增加。
Physical form
本品为溶于1x PBS缓冲液的纯化抗体,含0.09% (w/v) 叠氮化钠和2%蔗糖。
Other Notes
合成肽位于以下区域内: GQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTY
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
Zhao L, et al.
Cells, 8(5), 474-474 (2019)
Proteolytic processing of Neuregulin-1
Willem M
Brain Research Bulletin, 126(5), 178-182 (2016)
beta-Site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways
Tamagno E, et al.
Journal of Neurochemistry, 92(3), 628-636 (2005)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB2100200-100UL | 04061836149383 |