Anti-SOX2 Antibody

SOX2 (sex-determining region Y-box 2) is a transcription factor that is made of 317 amino acids. It has a HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cells. This gene is located on human chromosome 3q26.3.

Recombinant fragment corresponding to a region within amino acids 1 and 291 of SOX2 (Uniprot ID#P48431)

Suggested starting dilutions are as follows: FACS: 1:50-1:200, ICC/IF: 1:100-1:1000, IHC-Fr: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:20000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects the breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]

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1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.

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