biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable, immunoblotting: suitable, immunofluorescence: suitable, immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ACE2(59272)
General description
血管紧张素转换酶2（ACE2）基因定位于人类染色体Xp22.2。该基因编码膜相关和分泌的酶。Ace 2是血管紧张素转换酶（ACE）的人类同源物，主要存在于内皮细胞上。在人类中，Ace2仅在心脏、肾脏和睾丸中表达。该蛋白质的特征在于N端PD和C端Collectrin样结构域（CLD）。
Immunogen
产生的抗体是针对对应于人ACE2的N端氨基酸的合成肽。
Biochem/physiol Actions
血管紧张素转化酶2（ACE2）通过将Ang I转化为Ang1-9来帮助血管紧张素（Ang）的成熟。它也可能在心脏和肾脏的局部肾素-血管紧张素系统（RAS）中起作用。Ace 2作为严重急性呼吸综合征-冠状病毒（SARS-CoV）和新型冠状病毒（SARS-CoV-2）的功能性受体，后者导致2019冠状病毒病（COVID-19）。Ace 2表达降低可能导致心血管疾病。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
Physical form
以浓度为1 mg/mL含0.02％叠氮化钠的PBS溶液提供。
Other Notes
可以使用阻断肽SBP3500978阻断该抗体的作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
M Donoghue et al.
Circulation research, 87(5), E1-E9 (2000-09-02)
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library. ACE2 has an apparent signal peptide, a single metalloprotease active site, and a transmembrane domain. The metalloprotease
S R Tipnis et al.
The Journal of biological chemistry, 275(43), 33238-33243 (2000-08-05)
A novel human zinc metalloprotease that has considerable homology to human angiotensin-converting enzyme (ACE) (40% identity and 61% similarity) has been identified. This metalloprotease (angiotensin-converting enzyme homolog (ACEH)) contains a single HEXXH zinc-binding domain and conserves other critical residues typical
Michael A Crackower et al.
Nature, 417(6891), 822-828 (2002-06-21)
Cardiovascular diseases are predicted to be the most common cause of death worldwide by 2020. Here we show that angiotensin-converting enzyme 2 (ace2) maps to a defined quantitative trait locus (QTL) on the X chromosome in three different rat models
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SBP3500978-0.05MG | 04061832174280 |
| SAB3500978-100UG | 04061832497938 |