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Merck
CN

SAB4100599

Anti-KRAS Antibody

mouse monoclonal, KRAS-A582

别名:

Anti-C-K-RAS, Anti-K-RAS2A, Anti-K-RAS2B, Anti-K-RAS4A, Anti-K-RAS4B

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
KRAS-A582, monoclonal
Application:
WB
Citations:
29
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产品名称

Anti-KRAS antibody, Mouse monoclonal, clone KRAS-A582, purified from hybridoma cell culture

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

KRAS-A582, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 27.9 kDa

species reactivity

human

technique(s)

western blot: suitable using 5-10ug/ml using HEK-293 cells expressing KRAS

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRAS(3845)

General description

The kirsten rat sarcoma-2 virus oncogene (KRAS) gene is mapped to human chromosome 12p12.1 and belongs to the family of Ras genes. The protein encoded is a small guanosine nucleotide-bound GTPases belonging.

Immunogen

KRAS purified recombinant protein

Biochem/physiol Actions

Mutation in the KRAS gene causes non small-cell lung cancer and promotes tumor initiation, progression and metastasis. Altered KRAS gene also offers resistance to chemotherapy. It is involved in the signal transduction between epidermal growth factor receptor (EGFR) to the nucleus.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

法规信息

低风险生物材料
常规特殊物品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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RAS-expanded mutations and HER2 expression in metastatic colorectal cancer: a new step of precision medicine
Valentini AM, et al.
Applied Immunohistochemistry & Molecular Morphology, 26(8), 539-539 (2018)
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression
Jin H, et al.
Journal of Experimental & Clinical Cancer Research, 38(1), 165-165 (2019)
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
Tidyman WE and Rauen KA
Current Opinion in Genetics & Development, 19(3), 230-236 (2009)



全球贸易项目编号

货号GTIN
SAB4100599-200UL04061837786037