biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
J3-2, monoclonal
form
buffered aqueous solution
species reactivity
mouse, rat, dog, bovine, human, monkey
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 2.0-4.0 μg/mL using human liver tissue sections., western blot: 1.0-2.0 μg/mL using human placenta extracts.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COL4A1(1282)
General description
人胶原IV包含六个基因。COL4A1-COL4A2定位于13号染色体。COL4A3-COL4A4和COL4A5-COL4A6分别位于2号染色体和X号染色体上。它属于胶原超家族,并与基底膜(BMs)相关。六个α链,即α1(IV)至α6(IV)包含N端半胱氨酸和赖氨酸结构域,典型的Gly-X-Y三重重复序列和C端非胶原(NC1)结构域。
Immunogen
胎盘制剂富含基底膜胶原蛋白。
Application
小鼠抗IV型胶原单克隆抗体可用于:
- 免疫组织化学染色
- 免疫染色
- 免疫荧光检测
- 作为免疫印迹分析的二抗
Biochem/physiol Actions
胶原蛋白IV在基底膜组装中起关键作用。六个链组装成三个不同的原体,即α 1.α1.α2(IV)、α3.α4.α5(IV)和α 5.α5.α6(IV)。三聚体以α-链的不同组合形成。在专门的肾小球BM(GBM)中观察到α3、α4和α5的高表达水平。COlA5基因的突变与Alport综合征有关,而α3(IV)链与Goodpasture综合征(一种自身免疫性疾病)的发病机制有关。COlA5中的突变也与弥漫性食管平滑肌瘤病有关。
Physical form
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Mona G Amer et al.
International journal of immunopathology and pharmacology, 30(1), 13-24 (2017-03-11)
Liver disease remains a significant global health problem. Increased caffeine consumption has been associated with a lower prevalence of chronic liver disease. This study aimed to investigate the modifying effects of caffeine on liver injury induced by thioacetamide (TAA) administration
Collagen IV in normal skin and in pathological processes
Abreu-Velez AM and Howard MS
North American Journal of Medical Sciences, 4(1), 1-1 (2012)
Mammalian collagen IV
Khoshnoodi J, et al.
Microscopy Research and Technique, 71(5), 357-370 (2008)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200500-200UL | 04061837884290 |