SAB4200721
抗-GABA抗体，小鼠单克隆
clone GB-69, purified from hybridoma cell culture
别名:
Mouse Anti-Gamma-aminobutyric acid
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
GB-69, monoclonal
Species reactivity:
rat, monkey, frog, mouse, human, gerbil
Application:
DB, ELISA, IF, IHC
Citations:
3
biological source
mouse
Quality Level
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
GB-69, monoclonal
form
buffered aqueous solution
species reactivity
rat, monkey, frog, mouse, human, gerbil
concentration
~1.0 mg/mL
technique(s)
ELISA: suitable, dot blot: suitable, immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line, immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)
General description
小鼠单克隆抗GABA抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞与纯化BSA偶联GABA免疫的小鼠脾细胞融合产生的GB-69 杂交瘤。γ-氨基丁酸（GABA）存在于脊椎动物的中枢神经系统（CNS）中。谷氨酸脱羧酶（GAD）催化L-谷氨酸的酶促脱羧反应，形成GABA。
Immunogen
与BSA偶联的纯化的GABA
Application
小鼠单克隆抗GABA抗体已被用于：
- 免疫荧光
- 免疫组织化学
- 酶链免疫吸附检测 (ELISA)
- 斑点印迹
Biochem/physiol Actions
γ-氨基丁酸（GABA）是主要的抑制性神经递质。GABA介导快速的中枢神经系统突触抑制，并作为感觉回路在功能发育中起关键作用。GABA促进免疫细胞、胚胎干细胞和皮质祖细胞的增生。此外，它还涉及蛋白质合成和代谢，并在肌肉张力、血压、心率和呼吸的调节中起重要作用。
Physical form
0.01 M 磷酸盐缓冲液 (pH 7.4) 中的溶液，含 15 mM 叠氮化钠
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium
Ring H, et al.
PLoS ONE, 7(5), e36874-e36874 (2012)
Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with gamma-aminobutyric acid
Adrio F, et al.
The Journal of Comparative Neurology, 519(6), 1115-1142 (2011)
Kunihiko Obata
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 89(4), 139-156 (2013-04-12)
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons. γ-Aminobutyric acid (GABA), non-protein amino acid formed by decarboxylation of glutamic acid, is
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200721-100UL | 04061838037770 |