SAB4200742
抗 c-Myc过氧化物酶抗体，小鼠单克隆
clone 9E10, purified from hybridoma cell culture
别名:
抗-MRTL, 抗 v-myc禽骨髓瘤病病毒致癌基因同源物, 抗Myc, 抗bHLHe39
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关于此项目
NACRES:
NA.56
UNSPSC Code:
12352203
Conjugate:
peroxidase conjugate
Clone:
9E10, monoclonal
Application:
IHC
Citations:
14
biological source
mouse
Quality Level
conjugate
peroxidase conjugate
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
9E10, monoclonal
form
lyophilized powder
species reactivity
human
packaging
vial of 100 μL, vial of 500 μL
concentration
~2 mg/mL
technique(s)
immunoblotting: 1:250-1:500 using lysate of HEK-293T cells over expressing c-Myc fusion protein, immunohistochemistry: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MYC(4609)
General description
c-Myc单克隆抗体（小鼠IgG1亚型）来源于小鼠骨髓瘤细胞和KLH偶联人p62c-myc蛋白合成多肽免疫的BALB/c小鼠脾细胞融合而产生的9E10杂交瘤细胞。c-Myc是位于人类8号染色体长臂上的原癌基因。编码蛋白含有N端转录激活结构域。人c-Myc原癌基因是在几种致白血病逆转录病毒中发现的禽类v-Myc基因的人细胞同源物。
Immunogen
人 p62c-myc 蛋白的合成肽。
Application
小鼠抗c-Myc-过氧化物酶单克隆抗体可用于免疫印迹和免疫组化技术。
Biochem/physiol Actions
c-Myc是一种参与细胞生长、增殖、分化和凋亡调节的转录因子。与DNA复制、RNA剪接或转录有关。该基因过表达与多种人类癌症的发生发展有关。
调宁蛋白单克隆抗体特异性识别平滑肌调宁蛋白(Calponin)。
Physical form
以冻干粉形式提供。用0.1 mL蒸馏水重悬(reconstitution)至∼ 2 mg/mL的最终抗体浓度，溶液为含有1% BSA、2.5% 海藻糖和0.05% MIT的0.01M 磷酸钠缓冲液
Preparation Note
冻干产品2–8 °C储存。重新配制(reconstitution)后，若要延长储存时间，请以等分试样储存于-20°C。应避免反复冻融循环。重新配制(reconstitution)后如需继续使用，可在2-8 °C下储存至多一月。稀释的工作溶液在12小时后应当被丢弃。
Disclaimer
除非我们的产品目录另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Ann-Marie Baker et al.
Histopathology, 69(2), 222-229 (2016-01-31)
Recent attempts to study MYC distribution in human samples have been confounded by a lack of agreement in immunohistochemical staining between antibodies targeting the N-terminus and those targeting the C-terminus of the MYC protein. The aim of this study was
K Alitalo et al.
Nature, 306(5940), 274-277 (1983-11-17)
The myelocytomatosis viruses are a family of replication-defective avian retroviruses that cause a variety of tumours in chickens and transform both fibroblasts and macrophages in culture through the activity of their oncogene v-myc. A closely related gene (c-myc) is found
S Pelengaris et al.
Current opinion in genetics & development, 10(1), 100-105 (2000-02-19)
The protein products of many dominant oncogenes are capable of inducing both cell proliferation and apoptosis. Recent experiments employing transgenic mice that express an ectopically regulatable myc gene or protein have begun to elucidate the role of the balance between
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200742-1VL | 04061833350966 |
| SAB4200742-500UL | 04065271044470 |