产品名称
抗-GAPDH 兔抗, affinity isolated antibody
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~37 kDa
species reactivity
human, rat, mouse
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(P-A-K-Y-D)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GAPDH(2597)
General description
同时具有 3-磷酸甘油醛脱氢酶和亚硝化酶的活性，从而分别在糖酵解和核功能中起作用。参与转录、RNA 转运、DNA 复制和凋亡等核事件。核功能可能是由于亚硝化酶活性，其通过相似性介导 SIRT1、HDAC2 和 PRKDC 等核靶蛋白的半胱氨酸 S-亚硝化。3-磷酸甘油醛脱氢酶是糖酵解途径中的关键酶，可通过将 D-甘油醛 3-磷酸（G3P）转化为 3-磷酸-D-甘油酰磷酸来催化该途径的第一步。
甘油醛-3-磷酸脱氢酶（GAPDH）是一种多功能蛋白质，位于染色体12p13上。它本质上被称为糖酵解酶。
该抗体检测内源性总GAPDH蛋白水平。
该抗体检测内源性总GAPDH蛋白水平。
Immunogen
氨基酸 252-256 周围的肽序列（P-A-K-Y-D），根据蛋白质 NP_002037.2
Application
抗 GAPDH 抗体已用于蛋白质印迹。{60,61}
Biochem/physiol Actions
甘油醛-3-磷酸脱氢酶（GAPDH）在DNA修复中发挥重要作用。它对于糖酵解的第六步必不可少。它会参与转录和转录后的基因调控。它还控制细胞膜内运输和细胞死亡。GAPDH的累积会导致线粒体功能失调。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
Physical form
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Pingting Liu et al.
Disease models & mechanisms, 10(1), 53-62 (2016-12-10)
The S113R mutation (c.339T>G) (MIM #603690.0001) in SLC33A1 (MIM #603690), an ER membrane acetyl-CoA transporter, has been previously identified in individuals with hereditary spastic paraplegia type 42 (SPG42; MIM #612539). SLC33A1 has also been shown to inhibit the bone morphogenetic
Yanwu Hu et al.
Molecular medicine reports, 13(3), 2899-2903 (2016-01-29)
Icariin, a flavonoid isolated from the traditional Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess anti-inflammatory, anti‑oxidant and anti-atherosclerotic activities in vivo and in vitro. The aim of the present study was to investigate the effects of
Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in DNA Repair
Kosova AA, et al.
Biochemistry. Biokhimiia (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4300645-100UG | 04061832705354 |