Anti-p15 INK antibody produced in rabbit

Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

Cyclin-dependent kinase inhibitor 2B (CDKN2B) gene codes for tumor-suppressor p15INK4B protein. p15INK4B is a member of the INK4 family of protein kinase inhibitors. In bone marrow cells, p15INK4B expression is mainly seen at a high level in maturing monocytes/macrophages and lymphocytes. It is located in the nucleus and cytoplasm. The CDKN2B gene is mapped to human chromosome 9p21.3. Anti-p15 INK Antibody detects endogenous levels of total p15 INK protein.

The antiserum was produced against synthesized peptide derived from human p15 INK.

Immunogen Range: 89-138

Anti-p15 INK antibody produced in rabbit has been used in western blot (1:500).

Cyclin-dependent kinase inhibitor 2B (CDKN2B) plays a key role in the cell cycle and senescence. It participates in the differentiation of the hematopoietic cell. CDKN2B gene is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL). Homozygous deletion of the CDKN2B gene or p15INK4B locus on chromosome results in glioblastoma multiforme (GBM). Silencing of p15INK4B is associated with myelodysplastic syndromes, leukemia, and myeloproliferative diseases.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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