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CN

SAB4500662

抗-蛋白聚糖(裂解-Asp369),N-端 兔抗

affinity isolated antibody

别名:

CSPCP, CSPG1, 硫酸软骨素蛋白聚糖核心蛋白1, 蛋白聚糖核心蛋白, 软骨特异性蛋白聚糖核心蛋白

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
10
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

proteolytically cleaved (Asp369)

Gene Information

human ... ACAN(176)

General description

抗-聚集蛋白聚糖(裂解-Val369)抗体可检测激活聚集蛋白聚糖(裂解-Val369)蛋白片段的内源性水平。
聚集蛋白聚糖是人软骨的大聚集硫酸软骨素蛋白聚糖。它由AGC1(聚集蛋白聚糖)基因编码。它定位于人类染色体15q26.1。

Immunogen

该抗血清是针对衍生自人聚集蛋白聚糖的合成肽而生成的。

免疫原范围: 320-369

Application

N端抗聚集蛋白聚糖(裂解的Asp369)抗体已用于蛋白质印迹和免疫染色。

Biochem/physiol Actions

聚集蛋白聚糖的突变会导致常染色体显性遗传的矮小身材,并加速骨骼成熟。聚集蛋白聚糖基因(AGC1)的可变重复区域中的突变导致脊椎骨发育异常。

Features and Benefits

完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。

Physical form

兔IgG,溶于磷酸盐缓冲液(不含Mg2+和Ca2+),pH 7.4,150mM NaCl,0.02%叠氮化钠和50%甘油中。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

低风险生物材料
常规特殊物品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege K J, et al.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)
Feng-Lai Yuan et al.
Cell stress & chaperones, 21(1), 97-104 (2015-09-20)
Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its activation is associated with endplate chondrocyte apoptosis. However, the precise role
Zhoulong Yu et al.
Frontiers in molecular neuroscience, 13, 4-4 (2020-03-03)
Perineuronal nets (PNNs) are condensed extracellular matrix (ECM) structures regulating developmental plasticity and protecting neurons against oxidative stress. PNN abnormalities have been observed in various psychiatric disorders such as schizophrenia and bipolar disorder, but the relationship between PNN density and



全球贸易项目编号

货号GTIN
SAB4500662-100UG04061837744105