SAB4501984
抗-NRF2 兔抗
affinity isolated antibody
别名:
HEBP1, NF-E2相关因子2, NF2L2, NFE2L2, NFE2相关因子2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
17
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 67 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NFE2L2(4780)
General description
Nrf2 （核因子，红细胞2 相关因子2）基因位于人类染色体2q31.2。该编码蛋白位于树突状细胞。它属于转录因子的cap ′n′ collar (CNC) 家族。
抗-NRF2抗体检测内源性总NRF2蛋白水平。
Immunogen
抗血清通过靶向来自人Nrf2的合成肽产生。
免疫原范围： 556-605
免疫原范围： 556-605
Application
兔中产生的抗-NRF2，C-末端抗体已被用于蛋白质印迹分析中。
Biochem/physiol Actions
Nrf2 （核因子，红细胞2 相关因子2）参与抗氧化和抗炎反应的调节。该编码蛋白是一种转录因子，与靶基因的抗氧化反应元件结合。出于对氧化应激的响应，Nrf2上调与解毒、抗炎、细胞保护和抗氧化通路相关的酶的水平。通过调节磷酸戊糖途径，Nrf2影响癌症细胞中的葡萄糖代谢和ROS（活性氧）稳态。因此，现已确知Nrf2通过促进细胞增殖促使癌症发生。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Xin Liu et al.
Biochimica et biophysica acta, 1863(8), 2093-2103 (2016-05-18)
The cap 'n' collar (CNC) family of transcription factors play important roles in resistance of oxidative and electrophilic stresses. Among the CNC family members, NF-E2-related factor 2 (Nrf2) is critical for regulating the antioxidant and phase II enzymes through antioxidant
Martin Adam et al.
International journal of cardiology, 228, 341-346 (2016-11-21)
Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a
Daihong Cao et al.
Molecular medicine reports, 25(6) (2022-04-28)
It has been reported that oxidative stress plays a prominent role in diabetic macrovascular diseases. 3,4‑Dihydroxyacetophenone (3,4‑DHAP) has been found to have a variety of biological activities. However, few studies have assessed the antioxidant capacity of 3,4‑DHAP and the underlying
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4501984-100UG | 04061837745089 |