SAB4502022
抗-NOTCH2 (Cleaved-Val1697) 兔抗
affinity isolated antibody
别名:
Motch B, NOTC2, NOTCH2, NTC2, 跨膜受体蛋白2前体
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
6
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 83 kDa
species reactivity
human, rat, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Val1697)
Gene Information
human ... NOTCH2(4853)
General description
抗-NOTCH2(Cleaved-Val1697)抗体可检测激活的NOTCH2(Cleaved-Val1697)蛋白。
Immunogen
针对人源 NOTCH2 的合成肽产生抗血清。
免疫原范围：1678-1727
免疫原范围：1678-1727
Biochem/physiol Actions
现已确知NOTCH2基因参与癌症细胞的增殖、细胞周期进展和集落形成。在肝细胞癌和唾液腺腺样囊性癌中观察到该基因上调。NOTCH2 的敲除增加了癌细胞对化疗药物（如5-氟脲嘧啶）的敏感性。NOTCH2在肝脏发育的调节中起重要作用。
Features and Benefits
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Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Giuseppina Catanzaro et al.
International journal of molecular sciences, 18(12) (2017-12-21)
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c
Wen-Rui Wu et al.
Oncology reports, 36(1), 181-188 (2016-05-26)
The Notch pathway plays an important role in both stem cell biology and cancer. Notch2 was reported to be upregulated in human hepatocellular carcinoma (HCC) tissues. However, the biological function of Notch2 in human HCC cells has not yet been
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4502022-100UG | 04061837174131 |