Anti-pan-Actin Antibody

Anti-Actin-pan antibody detects endogenous levels of total actin-pan protein.

The ACTA1 (actin, α1) gene is mapped to human chromosome 1q42.13. The gene codes for actin 1, a thin filament component of skeletal muscle.

The antiserum was produced against synthesized peptide derived from human Actin.

Immunogen Range: 21-70

Mutations in ACTA1 (actin, α1) is known to cause thin filament myopathy, such as nemaline myopathy, congenital myopathy, actin myopathy, intranuclear rod myopathy, cap myopathy and core myopathy. Upregulation of the gene is observed in orthotopic liver transplantation without any earlier evidence of autoimmune liver disease. The encoded protein actin forms a network of filaments and is responsible for the shape of the cell. It provides cellular strength and promotes active movement of the cell.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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