SAB4503069
Anti-Vinculin Antibody
rabbit polyclonal
别名:
Metavinculin, VCL, VINC
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
13
产品名称
抗-黏着斑蛋白 兔抗, affinity isolated antibody
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 123 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VINC(7414)
General description
黏着斑蛋白（VCL）是一种广泛表达的细胞骨架蛋白，由定位于人类染色体10q11.2-qter 上的基因编码。VCL是粘附型细胞连接的重要成分。黏着斑蛋白结构包含一个球形头部，其通过富含脯氨酸的短序列连接到尾部结构域，头部与尾部之间的分子内相互作用掩盖了蛋白质中的各种配体结合位点。
Immunogen
针对人源粘着斑蛋白的合成肽产生抗血清。
免疫原范围：786-835
免疫原范围：786-835
Biochem/physiol Actions
黏着斑蛋白（VCL）是一种细胞骨架蛋白，可支持细胞与细胞和细胞与基质连接。它可控制粘附和运动以及细胞伸展，因此也基本参与了正常的胚胎发育和心脏功能。在成熟的黏着斑（FA）中，VCL是“分子离合器”的重要组成部分，“分子离合器”可将力从细胞质F-肌动蛋白传递至膜结合整合素。VCL的畸变或突变会导致心肌病，这与高血压有关。实验研究表明，VCL可作为衰老或心力衰竭的生物标志物。黏着斑蛋白与FA相关，参与多种细胞功能，如稳定和增强FA，促进其成熟、细胞外基质（ECM）机械敏感化，调节肌动蛋白的细胞骨架动力学和参与凋亡的信号转导途径。
Features and Benefits
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Physical form
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH 7.4，含150mM NaCl、0.02％叠氮化钠和50％甘油。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Qin Yu et al.
Scientific reports, 5, 15245-15245 (2015-10-22)
Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10
Tina Izard et al.
The Journal of biological chemistry, 291(6), 2548-2555 (2016-01-06)
The cytoskeletal protein vinculin is a major regulator of cell adhesion and attaches to the cell surface by binding to specific phospholipids. Structural, biochemical, and biological studies provided much insight into how vinculin binds to membranes, what components it recognizes
Darrell R Borger et al.
Biochemical and biophysical research communications, 370(2), 230-234 (2008-03-25)
This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4503069-100UG | 04061837745904 |