Anti-CASP-1 (Cleaved-Asp²¹⁰) antibody produced in rabbit

Anti-CASP-1 (Cleaved-Asp²¹⁰) Antibody detects endogenous levels of fragment of activated CASP-1 (Cleaved-Asp²¹⁰) protein.

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on human chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. CASP-1 is present in leukocytes, monocytes and epithelial cells.

The antiserum was produced against synthesized peptide derived from human IL-1 beta.

Immunogen Range: 161-210

Caspase-1 can transform pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. CASP-1 helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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