SAB5200113
Anti-Amyloid Precursor Protein (APP) Antibody
rabbit polyclonal
别名:
Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, IP, WB
Citations:
14
产品名称
Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
mouse, eukaryotes, rat, human
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... APP(351)
General description
Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.
Immunogen
Synthetic molecular mimic of soluble oligomers.
Application
Anti-APP antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.
Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).
Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
PBS, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Human brain-derived Abeta oligomers bind to synapses and disrupt synaptic activity in a manner that requires APP
Wang Z, et al.
The Journal of Neuroscience, 37(49), 11947-11966 (2017)
Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24. 3
Elliott C, et al.
Translational Psychiatry, 2(4), 179-179 (2018)
Protective effects of sulforaphane on cognitive impairments and ad-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity
Pu D, et al.
Neuroscience, 381, 35-45 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB5200113-100UL | 04061838059192 |