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SAB5300353

Monoclonal Anti-CASP8 antibody produced in mouse

Name: Monoclonal Anti-CASP8 antibody produced in mouse
Brand: SIGMA

clone 1H11, ascites fluid

别名:

ALPS2B, CAP4, FLICE, MACH, MCH5

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

1H11, monoclonal

Application:

ELISA (d), FACS, IHC, WB

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

1H11, monoclonal

mol wt

26 kDa

species reactivity

human, mouse, rat, monkey

technique(s)

direct ELISA: 1:10,000, flow cytometry: 1:200-1:400, immunohistochemistry: 1:200-1:1,000, western blot: 1:500-1:2,000

isotype

IgG1

NCBI accession no.

NM_001080124

UniProt accession no.

Q14790

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASP8(841)

说明

Immunogen

Purified recombinant fragment of human CASP8 expressed in E.coli.
Mouse monoclonal antibody raised against CASP8

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

nwg

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

PM1108292

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Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Ulrike Heinicke et al.

Cancer letters, 351(1), 50-58 (2014-05-13)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we identify a novel synthetic lethal interaction between the histone deacetylase inhibitor (HDACI) SAHA and anticancer drugs in

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Changyou Li et al.

Molecular oncology, 8(7), 1220-1230 (2014-05-13)

Little is known regarding molecular markers in head and neck squamous cell carcinoma (HNSCC) that predict responsiveness to different therapeutic regimens or predict HNSCC progression. Mutations in procaspase-8 occur in 9% of HNSCC primary tumors, but the functional consequences of

Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speciﬁc apoptosis.

Hanghui Wang et al.

International journal of oncology, 45(1), 157-164 (2014-04-17)

The specific and efficient delivery of small interfering RNA (siRNA) into cancer cells in vivo remains a major obstacle. In this study, we investigated whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of HSP72 and HSC70 in prostate cancer cell

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全球贸易项目编号

货号	GTIN
SAB5300353-100UL	04061837600272