SAB5600047
兔抗BRAF (V600E)单克隆抗体
recombinant, expressed in HEK 293 cells, clone RM8, purified immunoglobulin
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
RM8, monoclonal, recombinant monoclonal
Application:
ELISA, ICC, IHC
Citations:
4
recombinant
expressed in HEK 293 cells
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM8, monoclonal, recombinant monoclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 0.5-2 μg/mL, immunoblotting: 0.5-2 μg/mL, immunocytochemistry: 0.5-5 μg/mL, immunohistochemistry: 0.5-5 μg/mL
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BRAF(673)
General description
BRAF（B-Raf 原癌基因）是一种丝氨酸-苏氨酸激酶，编码 B-Raf 蛋白。它位于人类染色体7q34上。
Immunogen
对应于BRAF V600E突变体的肽
Biochem/physiol Actions
BRAF（B-Raf 原癌基因）参与细胞生长的直接信号传导。它通过在皮肤黑色素瘤、甲状腺癌和结肠癌等各种肿瘤中启动丝裂原活化蛋白激酶 (MAPK) 途径，诱导肿瘤生长。
该抗体与BRAF V600E突变体反应。与野生型BRAF无交叉反应。
Features and Benefits
请完全放心地评估我们的抗体。如果抗体在您的研究中无效，我们将全额退款或换货。了解更多。
Physical form
溶于含有50％甘油、1％BSA和0.09％叠氮化钠的磷酸盐缓冲盐水中。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
常规特殊物品
此项目有
The significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases: The implications for BRAF inhibitor therapy.
Hannan EJ, et al.
Medicine, 96(48), e8404-e8404 (2017)
Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study.
Shinozaki E, et al.
British Journal of Cancer, 117(10), 1450-1450 (2017)
Eli E Bar et al.
Journal of neuropathology and experimental neurology, 67(9), 878-887 (2008-08-22)
Relatively little is known about the molecular changes that promote the formation or growth of pilocytic astrocytomas. We investigated genomic alterations in 25 pilocytic astrocytomas, including 5 supratentorial and 20 posterior fossa tumors, using oligonucleotide array comparative genomic hybridization. Large
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB5600047-100UG | 04061829641054 |
| SAB5600047-50UG | 04022536389127 |