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SAB5700366

Anti-Phospho-Rb-S807/811 antibody produced in rabbit

Name: Anti-Phospho-Rb-S807/811 antibody produced in rabbit
Brand: SIGMA

别名:

OSRC, PPP1R130, RB, RB1, Rb, p105-Rb, pRb, pp110

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Clone:

polyclonal

Species reactivity:

human

Application:

Citations:

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属性

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

106

species reactivity

human

concentration

4.05 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

P06400

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer807/811)

Gene Information

human ... RB1(5925)

说明

General description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Immunogen

A synthetic phosphorylated peptide around S807 & S811 of human Rb (NP_000312.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c