主要文件

查看所有文档

SBR00011

克拉霉素，现成溶液

Name: 克拉霉素，现成溶液
Brand: SIGMA

Ready Made Solution, 50 mg/mL in DMSO

别名:

6-O-甲基红霉素

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₃₈H₆₉NO₁₃

化学文摘社编号:

81103-11-9

分子量:

747.95

UNSPSC Code:

51102829

PubChem Substance ID:

329824644

NACRES:

NA.85

MDL number:

MFCD00865140

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

200

form

liquid, ready-to-use solution

storage condition

dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)

concentration

50 mg/mL in DMSO

color

colorless to faint yellow

antibiotic activity spectrum

Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C

InChI

1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI key

AGOYDEPGAOXOCK-KCBOHYOISA-N

说明

General description

克拉霉素是一种大环内酯类抗生素，具有抗菌和抗炎作用。它是红霉素 A 的半合成 14 元衍生物，在酸性条件下抗降解。

Application

克拉霉素可用于-

研究克拉霉素对动脉灌注兔左心室楔形制剂的 QT、T_p-e 和促心律失常事件的速率依赖性变化的影响
表达 GFP（绿色荧光蛋白）的寄生虫的培养靶向顶质体，以进一步进行显微镜分析
NAB741 与克拉霉素在微量滴定板中的协同作用研究。

Biochem/physiol Actions

大环内酯类，如克拉霉素，通过与 50S 核糖体亚基结合，阻止细菌中的蛋白质合成。它还与其他核糖体蛋白结合，并阻止肽-dyl-tRNA 的易位。在难治性哮喘患者中，它能够调节白细胞介素 8（IL-8）的水平，以及中性粒细胞在肺中的积聚和活化。因此，它可能被用作哮喘的附加疗法，以减少非嗜酸性气道炎症。

Packaging

2ML

Preparation Note

保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）可燃液体。

Other Notes

保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体

Still not finding the right product?

Explore all of our products under 克拉霉素，现成溶液

存储类别

10 - Combustible liquids

flash_point_f

188.6 °F

flash_point_c

87 °C

pictograms

GHS09

signalword

Warning

hcodes

H410

pcodes

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

026M4056V

11151207

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

Jodie L Simpson et al.

American journal of respiratory and critical care medicine, 177(2), 148-155 (2007-10-20)

Patients with refractory asthma have persistent symptoms despite maximal treatment with inhaled corticosteroids and long-acting bronchodilators. The availability of add-on therapies is limited, and effective add-on therapies that target noneosinophilic airway inflammation are needed. Macrolide antibiotics, such as clarithromycin, have

Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade.

Shaobin Jia et al.

British journal of pharmacology, 164(2), 308-316 (2010-12-25)

Drug-induced torsades de pointes (TdP) often occurs during bradycardia due to reverse use-dependence. We tested the hypothesis that inhibition or enhancement of late sodium current (I(Na,L) ) could modulate the drug-induced reverse use-dependence in QT and T(p-e) (an index of

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches.

Eric H Ekland et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3583-3593 (2011-07-13)

Malarial parasites have evolved resistance to all previously used therapies, and recent evidence suggests emerging resistance to the first-line artemisinins. To identify antimalarials with novel mechanisms of action, we have developed a high-throughput screen targeting the apicoplast organelle of Plasmodium

查看所有相关文献

全球贸易项目编号

货号	GTIN
SBR00011-2ML	04061838175335