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关于此项目
经验公式(希尔记法):
C32H43NO4
化学文摘社编号:
分子量:
505.69
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
InChI
1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
InChI key
WPTTVJLTNAWYAO-KPOXMGGZSA-N
Gene Information
human ... IKBKB(3551), KEAP1(9817), NFE2L2(4780), PPARG(5468)
General description
CDDO-Me 是一种合成的三萜类化合物,具有抗炎、抗肿瘤和细胞保护作用。它来源于天然产物齐墩果酸。
Application
CDDO甲酯(甲基巴多索隆)已用于在肝脏缺血再灌注损伤(IRI)中检测其对肝细胞膜转运蛋白(HMT)的调控和对胆汁淤积症的缓解作用。它也作为NF E2相关因子2(NRF2)的激活剂,用于研究其防止黑色素瘤细胞死亡的作用。
Biochem/physiol Actions
CDDO-Me可抑制炎症介质,如白介素-6(IL-6)、IL-10和IL-12。它可增强TNF和化疗试剂诱导的细胞凋亡。CDDO-Me具有抗骨肉瘤细胞增殖活性,通过激活内源性线粒体依赖型细胞凋亡通路,可增强化疗试剂的有效性。它可作为进展型和致死型前列腺癌的辅助治疗手段。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes.
Eitas T K, et al.
PLoS ONE, 12(9), e0184164-e0184164 (2017)
A synthetic triterpenoid, CDDO-Me, inhibits IKBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor KB?regulated gene products in human leukemic cells.
Shishodia S, et al.
Clinical Cancer Research, 12(6), 1828-1838 (2006)
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
Tran T A, et al.
Journal of Neuroinflammation, 5(1), 1-1 (2008)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SMB00376-100MG | 04061833051979 |
| SMB00376-10MG | 04061833051986 |