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SML0002

C646

Name: C646
Brand: SIGMA

≥98% (HPLC), p300/CBP histone acetyltransferase inhibitor, powder

别名:

4-[4-[[5-（4,5-二甲基-2-硝基苯基）-2-呋喃基] 亚甲基]-4,5-二氢-3-甲基-5-氧代-1H-吡唑-1-基] 苯甲酸

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关于此项目

经验公式（希尔记法）:

C₂₄H₁₉N₃O₆

化学文摘社编号:

328968-36-1

分子量:

445.42

UNSPSC Code:

12352200

PubChem Substance ID:

329825079

NACRES:

NA.77

MDL number:

MFCD01784780

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

C646, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

red to brown

solubility

DMSO: >25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O

InChI

1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-

InChI key

HEKJYZZSCQBJGB-UNOMPAQXSA-N

说明

Application

采用 C646 研究 p300 在慢性压迫性损伤大鼠慢性神经病理性疼痛中的作用。

Biochem/physiol Actions

C646 是 p300 和 CBP (p300/CBP) 组蛋白乙酰转移酶的强效、细胞渗透性和选择性抑制剂。C646 抑制 p300/CBP 影响多种转录因子如 NF-κ 的活性p53 和 MyoD 与生理学、疾病过程、海马突触可塑性、空间记忆和情境恐惧相关。

C646 是一种强效、竞争性、选择性组蛋白乙酰转移酶 (HAT) p300/CBP 抑制剂。

C646 是一种竞争性组蛋白乙酰转移酶 (HAT) p300/CBP 抑制剂，Ki 为 400 nM，与其他乙酰转移酶相比具有选择性。

Features and Benefits

该化合物是基因调控研究的特色产品。点击此处，发现更多特色基因调控产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

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商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

Jia Cao et al.

Nature communications, 8(1), 131-131 (2017-07-27)

Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused by increased intestinal permeability during diet-induced obesity promotes insulin resistance in mice. Here, we show that LPS induces endoplasmic reticulum

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation.

Veronica Garcia-Carpizo et al.

Epigenetics & chromatin, 11(1), 30-30 (2018-06-10)

The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodomains and most of them remain unexplored. We report that the bromodomains

Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury.

Zhuofeng Ding et al.

Frontiers in neuroscience, 12, 341-341 (2018-06-08)

Peripheral nerve injuries are generally associated with incomplete restoration of motor function. The slow rate of nerve regeneration after injury may account for this. Although many benefits of resveratrol have been shown in the nervous system, it is not clear

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货号	GTIN
SML0002-25MG	04061832632803
SML0002-5MG	04061837076534