主要文件

查看所有文档

SML0065

Tubacin

Name: Tubacin
Brand: SIGMA

≥98% (HPLC), histone deacetylase 6 (HDAC6) inhibitor, powder

别名:

N1-[4-[(2R,4R,6S)-4-[[（4,5-二苯基-2-恶唑基）硫代] 甲基]-6-[4-（羟甲基）苯基]-1,3-二恶烷-2-基] 苯基]-N8-羟基-辛二酰胺

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₄₁H₄₃N₃O₇S

化学文摘社编号:

537049-40-4

分子量:

721.86

UNSPSC Code:

12352200

PubChem Substance ID:

329825129

NACRES:

NA.77

MDL number:

MFCD18452824

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

Tubacin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

OCC1=CC=C(C=C1)[C@@H]2C[C@H](CSC3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)O[C@H](C6=CC=C(NC(CCCCCCC(NO)=O)=O)C=C6)O2

InChI

1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1

InChI key

BHUZLJOUHMBZQY-YXQOSMAKSA-N

说明

Application

Tubacin被用于研究 HDAC6 在膀胱癌细胞迁移和侵袭中的作用。

Biochem/physiol Actions

Tubacin 可触发活性氧的释放并介导不依赖 caspase-3 的 eb 病毒 (EBV) 阳性 Burkitt 淋巴瘤细胞凋亡。它可抑制急性淋巴细胞白血病 (ALL) 细胞的增殖，增强ALL细胞化疗效果。Tubacin 可预防大鼠中由于 Srpx2 表达降低引起的癫痫活动和神经元迁移缺陷。

Tubacin 是组蛋白去乙酰化酶 6 (HDAC6) 的选择性抑制剂，HDAC6 是一种主要参与许多细胞过程的细胞质 II 类组蛋白去乙酰化酶，包括错误折叠蛋白的降解、细胞迁移和细胞间相互作用。Tubacin 选择性抑制 HDAC6 介导的 α-微管蛋白去乙酰化。

选择性组蛋白去乙酰化酶 6 (HDAC6) 抑制剂

Features and Benefits

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Microtubule stabilization specifies initial neuronal polarization.

Harald Witte et al.

The Journal of cell biology, 180(3), 619-632 (2008-02-13)

Axon formation is the initial step in establishing neuronal polarity. We examine here the role of microtubule dynamics in neuronal polarization using hippocampal neurons in culture. We see increased microtubule stability along the shaft in a single neurite before axon

Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.

Junichi Kawada et al.

The Journal of biological chemistry, 284(25), 17102-17109 (2009-04-24)

Tubacin is a small molecule inhibitor of histone deacetylase 6 and blocks aggresome activity. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were generally killed by lower doses of tubacin than EBV-transformed lymphoblastoid cells (LCLs) or EBV-negative BL

HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression.

Hui Tao et al.

Cardiology, 133(1), 18-26 (2015-09-25)

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. HDAC6 is a transcriptional regulator of the histone deacetylase family, subfamily 2.

查看所有相关文献

全球贸易项目编号

货号	GTIN
SML0065-1MG	04061837076749
SML0065-5MG	04061832632919