SML0198
非诺多泮 甲磺酸酯
≥98% (HPLC)
别名:
Fenoldopam methanesulfonate
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关于此项目
经验公式（希尔记法）:
C16H16ClNO3 · CH4O3S
化学文摘社编号:
分子量:
401.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
266-612-7
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
mp
271 °C (lit.)
solubility
DMSO: ≥15 mg/mL at ~60 °C
storage temp.
room temp
SMILES string
CS(O)(=O)=O.Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23
InChI
1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
InChI key
CVKUMNRCIJMVAR-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812)
Application
Fenoldopam mesylate may be used to study dopamine D1-mediated cell signaling.
Biochem/physiol Actions
Fenoldopam mesylate (FM) is considered as an effective therapeutic agent to prevent the onset of postoperative AKI (PO-AKI). In healthy cats, FM can stimulate diuresis and be well-tolerated. This benzazepine-derivative is regional specific and does not cause cerebral vasodilation.
Dopamine D1-receptor agonist; Antihypertensive
Fenoldopam mesylate is a selective dopamine D1 receptor agonist used as an antihypertensive agent. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and α-adrenoceptors, 5HT1 and 5HT2 receptors, or muscarinic receptors. Fenoldopam mesylate causes peripheral vasodilation by stimulating dopamine-1receptors and α2-adrenoceptors, increasing renal blood flow.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
我们可提供多种多巴胺受体相关的产品，满足您的各类研究需求。
We offer many products related to dopamine receptors for your research needs.
51 What is the value of Non-Dialytic therapy in acute kidney injury
Evidence-Based Practice of Critical Care E-book: Expert Consult, 359-359 (2010)
Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury
Noce A, et al.
Current Pharmaceutical Biotechnology (2019)
The pharmacokinetics of intravenous fenoldopam in healthy, awake cats
O'Neill KE, et al.
Journal of Veterinary Pharmacology and Therapeutics, 39, 202-204 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0198-10MG | 04061832075136 |
| SML0198-50MG | 04061832075143 |