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SML0315

CORM-A1

≥95% (NMR), CO donor, powder

别名:

硼烷碳酸钠

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关于此项目

经验公式（希尔记法）:
CH3BNa2O2
化学文摘社编号:
17363-08-5
分子量:
103.82
UNSPSC Code:
12352200
PubChem Substance ID:
329825320
NACRES:
NA.77
MDL number:
MFCD18839226
Assay:
≥95% (NMR)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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产品名称

CORM-A1, ≥95% (NMR)

Quality Level

100

assay

≥95% (NMR)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: >15 mg/mL

storage temp.

room temp

SMILES string

[Na+].[Na+].[BH3-]C([O-])=O

InChI

1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1

InChI key

SOFPSQNQOQPAAJ-UHFFFAOYSA-M

Application

CORM-A1可用于：
  • 提供一氧化碳（CO）并测试其在酵母和原代星形胶质细胞培养基中氧化应激时的细胞保护作用
  • 作为小鼠巨噬细胞 J774A.1 中的 CO 供体，以测试其对细胞内啡呔升高的影响β
  • 测试其对视网膜神经节细胞自噬激活的影响

Biochem/physiol Actions

CORM-A1是一种水溶性一氧化碳（CO）释放分子。
CORM-A1是一种水溶性一氧化碳（CO）释放分子，可用于研究CO对细胞系统的影响。一氧化碳（CO）是在血红素加氧酶降解血红素过程中产生的一种重要的气体信号调节因子。CORM-A1在哺乳动物细胞中具有抗氧化和抗炎作用。
它以 pH 值和随温度变化的方式介导 CO 的释放，进而缓解轻度血管舒张和低血压。在氧化应激过程中，CORM-A1 可在星形胶质细胞原代培养基中提供细胞保护。这种含硼的 CORM 可促进自噬作用。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
026M4760V
042M4745V

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Kapil K Upadhyay et al.
Redox biology, 28, 101314-101314 (2019-09-13)
Nuclear factor-erythroid 2 related factor 2 (Nrf2)-mediated signaling plays a central role in maintaining cellular redox homeostasis of hepatic cells. Carbon monoxide releasing molecule-A1 (CORM-A1) has been reported to stimulate up-regulation and nuclear translocation of Nrf2 in hepatocytes. However, the
Kapil K Upadhyay et al.
Toxicology and applied pharmacology, 360, 99-108 (2018-10-03)
Acute liver injury is frequently associated with oxidative stress. Here, we investigated the therapeutic potential of carbon monoxide releasing molecule A-1 (CORM A-1) in oxidative stress-mediated liver injury. Overnight-fasted mice were injected with acetaminophen (APAP; 300 mg/kg; intraperitoneally) and were sacrificed
Rui-Gang Zhang et al.
Molecular immunology, 105, 205-212 (2018-12-16)
Carbon monoxide (CO) is an anti-inflammatory gaseous molecule produced endogenously by heme oxygenases (HOs) HO-1 and HO-2. However, the mechanisms underlying the anti-inflammatory effects of CO in the human bronchial epithelium are still not fully understood. In this study, the
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全球贸易项目编号

货号GTIN
SML0315-10MG04061833222492
SML0315-50MG04061833222508