SML0440
Spautin-1
≥98% (HPLC), Autophagy inhibitor, powder
别名:
6-氟-N-[（4-氟苯基）甲基]-4-喹唑啉胺, C43
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关于此项目
经验公式（希尔记法）:
C15H11F2N3
化学文摘社编号:
分子量:
271.26
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Spautin-1, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
SMILES string
FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
InChI
1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
InChI key
AWIVHRPYFSSVOG-UHFFFAOYSA-N
Application
Spautin-1 已作为自噬抑制剂用于：
- 研究其对氧诱导视网膜病变小鼠模型中血管、神经胶质和神经元改变的影响
- 评估预处理对犬骨肉瘤细胞阿霉素反应的效果
- 在 Luminex 试验中研究其对氧化应激树突状细胞 (OS-DC) 产生白细胞介素 (IL)-6 的影响
Biochem/physiol Actions
Spautin-1 抑制两种泛素特异性肽酶 USP10 和 USP13 的活性，引起 III 类 PI3 激酶复合物的蛋白酶体降解增加，已被证明可调节自噬。
Spautin-1 是一种自噬抑制剂。
特异性强的自噬抑制剂-1（Spautin-1）是一种小分子，可以抑制自噬并诱导癌细胞死亡。它可通过降解 beclin-1 来抑制自噬。Spautin-1 可提高放射治疗和化学疗法在各种人类癌细胞系中的效率。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
V Vasilca et al.
Analytical biochemistry, 549, 58-65 (2018-03-17)
Screening assays performed against membrane protein targets (e.g. phage display) are hampered by issues arising from protein expression and purification, protein stability in detergent solutions and epitope concealment by detergent micelles. Here, we have studied a fast and simple method
Alice Verchère et al.
Scientific reports, 2, 306-306 (2012-03-09)
We describe an original activity assay for membrane transport that uses the proton motive force-dependent efflux pump MexAB from Pseudomonas aeruginosa. This pump is co-reconstituted into proteoliposomes together with bacteriorhodopsin (BR), a light-activated proton pump. In this system, upon illumination
Daniel G Panaccione et al.
Scientific reports, 7(1), 8930-8930 (2017-08-23)
Neosartorya fumigata (Aspergillus fumigatus) is the most common cause of invasive aspergillosis, a frequently fatal lung disease primarily affecting immunocompromised individuals. This opportunistic fungal pathogen produces several classes of specialised metabolites including products of a branch of the ergot alkaloid
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0440-25MG | 04061837084546 |
| SML0440-5MG | 04061837084553 |