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SML0483

DpC

≥98% (HPLC)

别名:

Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone

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关于此项目

经验公式（希尔记法）:
C19H23N5S
化学文摘社编号:
1382469-39-7
分子量:
353.48
NACRES:
NA.77
PubChem Substance ID:
329825434
UNSPSC Code:
12352200
MDL number:
MFCD22666593
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

−20°C

SMILES string

CN(C1CCCCC1)C(=S)N\N=C(\c2ccccn2)c3ccccn3

InChI

1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)

InChI key

GNLZNQJBZNOUBM-UHFFFAOYSA-N

Biochem/physiol Actions

DpC is an iron-chelating agent.
DpC is an iron-chelating agent. In four separate human pancreatic tumor cell lines, DpC significantly increased the expression and phosphorylation of the growth and metastasis suppressor, N-myc down-stream regulated gene 1 (NDRG1) and the cdk inhibitpr p21CIP1/WAF. DpC completely blocked PANC-1 tumor growth in mouse xenografts.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
092M4615V

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Zaklina Kovacevic et al.
The Journal of biological chemistry, 291(3), 1029-1052 (2015-11-05)
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pathway, protein kinase B (AKT)/PI3K pathway, RAS, etc. To investigate the hypothesis
Ye-Xing Xu et al.
Oncology letters, 15(5), 7999-8004 (2018-05-10)
The present study aimed to investigate the antitumor efficacy of di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) and di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) on head and neck squamous cell carcinoma (HNSCC) cells. The proliferation and apoptosis of HNSCC cells treated with the iron chelators DpC and Dp44mT were
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全球贸易项目编号

货号GTIN
SML0483-5MG04061833066539
SML0483-25MG04061833066522