SML0493
T16Ainh-A01
≥95% (HPLC)
别名:
2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
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关于此项目
经验公式（希尔记法）:
C19H20N4O3S2
化学文摘社编号:
分子量:
416.52
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
room temp
SMILES string
CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
InChI
1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
InChI key
QSIYTNYMBWYHAA-UHFFFAOYSA-N
Application
T16Ainh-A01 已被用作跨膜蛋白 16A (TMEM16A) 的抑制剂。
Biochem/physiol Actions
T16Ainh-A01 是一种选择性 TMEM16A 钙激活氯离子通道抑制剂，可强烈抑制唾液腺细胞的氯电流。T16Ainh-A01 对肠道和气道上皮细胞的总 CaCC 电流的抑制作用较差，但主要阻断初始的、激动剂刺激的瞬时氯电流。T16Ainh-A01 不改变胞浆钙离子，对 CFTR Cl-电导几乎没有影响。
T16Ainh-A01 是选择性 TMEM16A 钙激活氯离子通道抑制剂...
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offer many products related to chloride channels for your research needs.
TMEM16A regulates portal vein smooth muscle cell proliferation in portal hypertension.
Zeng X, et al.
Experimental and Therapeutic Medicine, 15(1), 1062-1068 (2018)
Jinyu Zhang et al.
International journal of molecular sciences, 23(22) (2022-11-27)
Dry eye disease (DED) is a multifactorial disease with an incidence of approximately 50% worldwide. DED seriously affects quality of life and work. The prevalence of environmental DED (eDED) ranges from 35 to 48%. Conjunctival fluid secretion dysfunction may be
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0493-10MG | 04061837084713 |
| SML0493-50MG | 04061837084720 |