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SML0832

TLR4-IN-C34

Name: TLR4-IN-C34
Brand: SIGMA

≥98% (HPLC), toll-like receptor 4TLR4 inhibitor, powder

别名:

2-乙酰氨基吡喃糖苷, C34, 异丙基 2-（乙酰氨基）-2-脱氧 α-D-吡喃葡萄糖苷 3,4,6-三乙酸酯

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关于此项目

经验公式（希尔记法）:

C₁₇H₂₇NO₉

化学文摘社编号:

40592-88-9

分子量:

389.40

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

TLR4-IN-C34, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 1 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

N([C@H]1[C@H](O[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)COC(=O)C)OC(C)C)C(=O)C

InChI

1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1

InChI key

KMIQMFHPUJUDMC-HHARLNAUSA-N

说明

General description

TLR4-IN-C34 是体外和体内 toll 样受体 4（TLR4）的抑制剂。

Application

TLR4-IN-C34 已作为一种抑制剂用在喂食高脂饮食的小鼠中，以在体内验证上述体外途径（硬脂酸/LDH-α/细胞因子）。

Biochem/physiol Actions

TLR4-IN-C34 是 toll 样受体 4（TLR4）的有效和特异性抑制剂，其在体内和体外抑制 TLR4 信号转导。TLR4-IN-C34，也称为 C34，是一种氨基单糖，通过与 TLR4 的共同受体-髓样分化蛋白-2 (MD-2)的疏水口袋对接来抑制 TLR4 信号。研究表明，C34 可降低实验性坏死性小肠结肠炎（NEC）的严重程度。

TLR4-IN-C34 是 toll 样受体 4（TLR4）的有效特异性抑制剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

024M4760V

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The low-molecular weight isopropyl 2-acetamido-α-glucoside 16 (C34) inhibits toll-like receptor 4 (TLR4) in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. We used a copper(II)-mediated solvolysis of anomeric oxazolines and an

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Pharmacological inhibition of TLR4/NF-κB with TLR4-IN-C34 attenuated microcystin-leucine arginine toxicity in bovine Sertoli cells.

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Journal of applied toxicology : JAT, 39(6), 832-843 (2019-01-24)

This study investigated the pharmacological inhibition of the toll-like receptor 4 (TLR4) genes as a measure to attenuate microcystin-LR (MC-LR) reproductive toxicity. Bovine Sertoli cells were pretreated with TLR4-IN-C34 (C34) for 1 hour. Thereafter the pretreated and non-pretreated Sertoli cells were

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