SML0843
ISRIB
≥98% (HPLC), powder, integrated stress response inhibitor
别名:
反式-N,N′-1,4-环己烷二基双 \ [2-（4-氯苯氧基）-乙酰胺, 反式-N,N′-（环己烷-1,4-二基）双（2-（4-氯苯氧基）乙酰胺, 整合应激反应抑制剂
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C22H24Cl2N2O4
化学文摘社编号:
分子量:
451.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
ISRIB, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
ClC1=CC=C(OCC(N[C@@H]2CC[C@@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2)=O)C=C1
InChI
1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2,(H,25,27)(H,26,28)/t17-,18-
InChI key
HJGMCDHQPXTGAV-IYARVYRRSA-N
Application
ISRIB（综合应激反应抑制剂）已被用作综合应激反应的抑制剂。
Biochem/physiol Actions
ISRIB（综合应激反应抑制剂）作为一种药物，赋予细胞抵抗真核起始因子2（eIF2）α磷酸化（如激活转录因子4（ATF4）和真核翻译起始因子4E（eIF4E）结合）的下游作用的抗性 蛋白质1（4E-BP1）诱导。
ISRIB 是一种血脑屏障渗透剂，是内质网应激适应性受损的有效选择性综合应激反应 (ISR) 抑制剂。ISRIB 是 PERK 信号的有效抑制剂，可有效逆转 eIF2a 磷酸化作用，恢复细胞翻译能力。ISRIB 增强啮齿类动物的认知记忆。
ISRIB 是一种血脑屏障渗透剂，是强效选择性 PERK 信号通路抑制剂；认知记忆增强剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
B Balakrishnan et al.
Biochimica et biophysica acta. Molecular basis of disease, 1865(11), 165516-165516 (2019-07-31)
Loss of galactose-1 phosphate uridylyltransferase (GALT) activity in humans results in Classic Galactosemia, and the GalT-deficient (GalT-/-) mouse mimics the patient condition. GalT-/- ovaries display elevated endoplasmic reticulum (ER) stress marker, BiP, and downregulated canonical phosphatidylinositol 3-kinase (Pi3k)/protein kinase B
Z D Kabir et al.
Molecular psychiatry, 22(8), 1096-1109 (2017-06-07)
CACNA1C, encoding the Ca
Jeremy T Lant et al.
Nucleic acids research, 49(20), 11883-11899 (2021-11-01)
In neurodegenerative diseases, including pathologies with well-known causative alleles, genetic factors that modify severity or age of onset are not entirely understood. We recently documented the unexpected prevalence of transfer RNA (tRNA) mutants in the human population, including variants that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0843-25MG | 04061832451046 |
| SML0843-5MG | 04061832451053 |