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SML0868

嘌吗啡胺

Name: 嘌吗啡胺
Brand: SIGMA

≥98% (HPLC), powder, Hedgehog signaling activator

别名:

2-（1-萘基）-6-（4-吗啉苯胺）-9-环己嘌呤; 9-环己基-N- [4-（4-吗啉基）苯基]-2-（1-萘氧基）-

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关于此项目

经验公式（希尔记法）:

C₃₁H₃₂N₆O₂

化学文摘社编号:

483367-10-8

分子量:

520.62

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

嘌吗啡胺, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4

InChI

1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChI key

FYBHCRQFSFYWPY-UHFFFAOYSA-N

说明

Application

Purmorphamine已被用于研究Tupfel长鳍株斑马鱼中Hedgehog信号通路上调的影响。

Biochem/physiol Actions

Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。

Purmorphamine可直接结合Smoothened（Smo）受体，激活Hedgehog（Hh）信号通路。多项研究已经显示，Purmorphamine可诱导成骨细胞的分化、从人胚胎干细胞中产生心肌细胞、增加人纹状体神经干细胞系的神经元分化、以及将人脐带间充质干细胞（hUCMSC）分化成运动神经元。

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pictograms

GHS08

signalword

Warning

hcodes

H341

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.

Shabana Amanda Ali et al.

Arthritis & rheumatology (Hoboken, N.J.), 68(1), 127-137 (2015-09-01)

With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli-mediated transcriptional activation associated with increased

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.

Sara Brilha et al.

Scientific reports, 7(1), 16031-16031 (2017-11-24)

Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium

Methylation microarray studies highlight PDGFA expression as a factor in biliary atresia.

Cofer Z C, et al.

PLoS ONE, 11(3), e0151521-e0151521 (2016)

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全球贸易项目编号

货号	GTIN
SML0868-25MG	04061833224168
SML0868-5MG	04061837107290