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Merck
CN

SML1083

利尿酸

≥97% (HPLC), glutathione S-transferase inhibitor, powder

别名:

2-[2,3-二氯-4-(2-亚甲基-1-氧丁基)苯氧基] 乙酸, ECA, [2,3-二氯-4-(2-乙基丙烯酰基)苯氧基] 乙酸, 依他尼酸, (2,3-二氯-4-[2-亚甲基丁酰]苯氧基)乙酸

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关于此项目

经验公式(希尔记法):
C13H12Cl2O4
化学文摘社编号:
分子量:
303.14
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
200-384-1
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
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产品名称

利尿酸, ≥97% (HPLC)

Quality Level

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

Biochem/physiol Actions

依他尼酸可增加苯丁酸氮芥对大鼠和人肿瘤细胞系的细胞毒性。
依他尼酸是非磺胺类环状利尿剂,用于治疗高血压和充血性心力衰竭等疾病引起的水肿。依他尼酸可阻断钠-钾-氯离子共同转运。此外,依他尼酸可强效抑制谷胱甘肽 S-转移酶家族成员。研究显示,依他尼酸可有效抑制包括肺癌和胰腺癌在内的癌细胞的 Tgase-2(转谷氨酰胺酶-2)依赖性转移。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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E Röth et al.
Experimental and clinical cardiology, 16(3), 92-96 (2011-11-09)
Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study was
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.
Ploemen J H, et al.
Biochemical Pharmacology, 40(7), 1631-1635 (1990)
Piriyaporn Thiendedsakul et al.
Veterinary world, 15(1), 46-54 (2022-04-05)
The crocodile is a model for studying relevant sources of environmental contamination. They were determined an appropriate biomonitoring species for various toxins. The cytosolic and microsomal fraction of crocodiles plays a role in detoxifying xenobiotics. Cytochrome P450 1A2 (CYP1A2) metabolizes



全球贸易项目编号

货号GTIN
SML1083-10MG04061837107566