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SML1109

KU-55933

≥98% (HPLC), Ataxia telangiectasia (A-T) mutated (ATM) kinase inhibitor, powder

别名:

2-(4-吗啉基)-6-(1-噻蒽基)-4H-吡喃-4-酮, 2-(吗啉-4-基)-6-(噻蒽-1-基)-4H-吡喃-4-酮

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关于此项目

经验公式（希尔记法）:
C21H17NO3S2
化学文摘社编号:
587871-26-9
分子量:
395.49
UNSPSC Code:
12352200
PubChem Substance ID:
329825484
NACRES:
NA.77
MDL number:
MFCD08276985
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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产品名称

KU-55933, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C=C(OC(=C1)c2cccc3Sc4ccccc4Sc23)N5CCOCC5

InChI

1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChI key

XRKYMMUGXMWDAO-UHFFFAOYSA-N

Application

KU-55933已被用作共济失调-毛细血管扩张症突变（ATM）抑制剂。

Biochem/physiol Actions

KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂。
KU-55933是一种非常有效的共济失调毛细血管扩张症（A-T）突变（ATM）激酶特异性抑制剂（IC50 = 13 nM）。KU-22933处理可增强癌细胞对电离辐射和细胞毒性药物的敏感性。化合物KU-22933能够阻断ATM介导的p53、gH2AX、NBS1和SMC1的磷酸化。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
027M4731V
096M4705V
066M4748V
065M4701V
124M4725V

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全球贸易项目编号

货号GTIN
SML1109-25MG04061832434315
SML1109-5MG04061832434322