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SML1135

MG-132（R）

Name: MG-132（R）
Brand: SIGMA

≥95% (HPLC), membrane-permeable proteasome inhibitor, powder

别名:

ZL-LEU-d-LEU-L-LEU-al

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关于此项目

经验公式（希尔记法）:

C₂₆H₄₁N₃O₅

化学文摘社编号:

1211877-36-9

分子量:

475.62

UNSPSC Code:

12352200

PubChem Substance ID:

329825671

NACRES:

NA.32

MDL number:

MFCD28580122

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属性

产品名称

MG-132（R）, ≥95% (HPLC)

product line

SAFC Hitech^®

Quality Level

200

assay

≥95% (HPLC)

form

powder

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

O=C(N[C@H](CC(C)C)C(N[C@H](C=O)CC(C)C)=O)[C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

InChI key

TZYWCYJVHRLUCT-ZRBLBEILSA-N

Gene Information

human ... CTSB(1508), NFKB1(4790), PSMA1(5682)

说明

Biochem/physiol Actions

MG-132（R）是一种有效的膜透性蛋白酶体抑制剂。以10μM的浓度，它诱导PC12细胞中的神经突向外生长。BXI-132(R)可阻断聚（ADP-核糖）聚合酶的切割和胸腺细胞的凋亡。然而，MG-132（R）还可激活c-Jun N-末端蛋白激酶（JNK-1），其可响应细胞应激而启动细胞凋亡。蛋白酶体抑制可诱导热休克蛋白mRNA的积累、热休克蛋白的激活、以及增强各种细胞类型中的耐热性。

Legal Information

SAFC Hitech is a registered trademark of Sigma-Aldrich Co. LLC

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

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Lot/Batch Number

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The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.

Han YH

Oncology Reports, 22(1), 215-221 (2009)

TP53INP2 mediates autophagic degradation of ubiquitinated proteins through its ubiquitin-interacting motif.

Yinfeng Xu et al.

FEBS letters, 593(15), 1974-1982 (2019-06-04)

The tumor protein p53-inducible nuclear protein 2 (TP53INP2) has been reported to participate in autophagy by interacting with autophagosome-localized autophagy-related protein 8 (Atg8) family proteins, including LC3. Here, we uncover a novel function for TP53INP2 in the autophagic degradation of

Parkin-dependent and -independent degradation of synaptotagmin-11 in neurons and astrocytes.

Yalong Wang et al.

Neuroscience letters, 739, 135402-135402 (2020-09-26)

Synaptotagmin-11 (Syt11) is associated with schizophrenia and Parkinson's disease (PD) and is a critical substrate of parkin, an E3 ubiquitin ligase linked to PD. Previously we reported that Syt11 regulates multiple membrane trafficking pathways in neurons and glia. However, the

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全球贸易项目编号

货号	GTIN
SML1135-5MG	04061837107627