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SML1175

罗咪酯肽

Name: 罗咪酯肽
Brand: SIGMA

≥98% (HPLC), powder, histone deacetylase inhibitor

别名:

FK228, FR901228, L-缬氨酸, N-((3S,4E)-3-羟基-7-巯基-1-氧代-4-庚基)-D-戊基-D-半胱氨酸-(2Z)-2-氨基-2-丁烯氧基-, (4-1)-内酯,环状(1-2)-二硫化物, 环[(2Z)-2-氨基-2-丁烯酰基-L-戊基-(3S,4E)-3-羟基-7-巯基-4-庚烯酰基-D-戊基-D-半胱氨酰]环状(35)-二硫化物, 缩酚酸肽

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关于此项目

经验公式（希尔记法）:

C₂₄H₃₆N₄O₆S₂

化学文摘社编号:

128517-07-7

分子量:

540.70

UNSPSC Code:

12352200

PubChem Substance ID:

329825701

NACRES:

NA.77

MDL number:

MFCD18433404

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

罗咪酯肽, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=C\C)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O

InChI

1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1

InChI key

OHRURASPPZQGQM-GCCNXGTGSA-N

Gene Information

human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

说明

Biochem/physiol Actions

罗米地辛可促进细胞凋亡，同时阻碍神经胶质瘤模型中肿瘤的生长。

罗米地辛是HDAC1和HDAC2的一种非常有效的天然前药抑制剂，可被谷胱甘肽转化为活性形式。罗米地辛对HDAC1和HDAC2的IC₅₀ 值分别为36 nM和47 nM。它可杀死过表达Bcl-2和Bcl-XL的淋巴瘤细胞系，并已被批准用于治疗皮肤T细胞淋巴瘤（CTCL）和外周T细胞淋巴瘤，以及多种其他癌症。

罗米地辛是HDAC1和HDAC2的非常有效的天然前药抑制剂；抗肿瘤药。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

114M4707V

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Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors.

Qin Xu et al.

American journal of physiology. Heart and circulatory physiology, 311(5), H1139-H1149 (2016-11-03)

Histone deacetylase (HDAC) inhibitors are small molecule anticancer therapeutics that exhibit limiting cardiotoxicities including QT interval prolongation and life-threatening cardiac arrhythmias. Because the molecular mechanisms for HDAC inhibitor-induced cardiotoxicity are poorly understood, we performed whole cell patch voltage-clamp experiments to

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.

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Nature communications, 8, 14290-14290 (2017-01-31)

Peripheral T-cell lymphomas (PTCL) are aggressive diseases with poor response to chemotherapy and dismal survival. Identification of effective strategies to target PTCL biology represents an urgent need. Here we report that PTCL are sensitive to transcription-targeting drugs, and, in particular

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.

Sina Jostes et al.

Journal of cellular and molecular medicine, 21(7), 1300-1314 (2016-12-28)

Type II testicular germ cell cancers (TGCT) are the most frequently diagnosed tumours in young men (20-40 years) and are classified as seminoma or non-seminoma. TGCTs are commonly treated by orchiectomy and chemo- or radiotherapy. However, a subset of metastatic

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全球贸易项目编号

货号	GTIN
SML1175-1MG	04061826274460