产品名称
4-Hydroxytamoxifen Ready Made Solution, 5 mg/mL in ethanol: isopropanol (95:5)
biological source
synthetic
Quality Level
form
solution
concentration
5 mg/mL in ethanol: isopropanol (95:5)
shipped in
dry ice
storage temp.
−20°C
SMILES string
N(CCOc1ccc(cc1)\C(=C(\CC)/c3ccccc3)\c2ccc(cc2)O)(C)C
InChI
1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
InChI key
TXUZVZSFRXZGTL-QPLCGJKRSA-N
Biochem/physiol Actions
4-羟基他莫昔芬的反式 异构体具有抗雌激素活性，而 顺式 4-羟基他莫昔芬是雌激素受体的关键激动剂。4-羟基他莫昔芬通过激活 乳腺癌细胞中p38 通路促进凋亡。
4-羟基他莫昔芬是他莫昔芬的活性代谢产物。
4-羟基他莫昔芬是他莫昔芬的活性代谢产物。4-羟基他莫昔芬在人肝脏中由细胞色素 P450 2D6 形成，是一种强效选择性雌激素受体拮抗剂。4-羟基他莫昔芬用于刺激 LC3 脂化，并以超氧化物依赖的方式形成自噬囊泡。在原代培养的人肝细胞中，他莫昔芬和 4-羟基他莫昔芬显著诱导细胞色素 P450 3A4（一种主要的药物代谢酶）。4-羟基他莫昔芬经历反 (E-Z) 异构化—这一过程发生在所有常见的实验室溶剂中。
Preparation Note
4-羟基他莫昔芬为 13 mM 溶液。推荐工作浓度为 10-100μM。因此，4-羟基他莫昔芬制备液应在细胞培养基中以 1:130-1:1,300 稀释。
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
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signalword
Danger
Hazard Classifications
Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
55.4 °F
flash_point_c
13 °C
法规信息
危险化学品
此项目有
Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis.
Zhang C C and Shapiro D J
The Journal of Biological Chemistry, 275(1), 479-486 (2000)
Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants.
Sun D, et al.
Breast Cancer Research, 8(4), R50-R50 (2006)
Izumi Kaji et al.
JCI insight, 6(16) (2021-07-02)
Functional loss of myosin Vb (MYO5B) induces a variety of deficits in intestinal epithelial cell function and causes a congenital diarrheal disorder, microvillus inclusion disease (MVID). The impact of MYO5B loss on differentiated cell lineage choice has not been investigated.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1666-1ML | 04061838093042 |