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SML1713

卡洛芬

≥97% (HPLC), COX-2 inhibitor, powder

别名:

6-氯-α-甲基-9 H -咔唑-2-乙酸

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关于此项目

经验公式（希尔记法）:
C15H12ClNO2
化学文摘社编号:
53716-49-7
分子量:
273.71
NACRES:
NA.77
PubChem Substance ID:
329826035
UNSPSC Code:
12352200
EC Number:
258-712-4
MDL number:
MFCD00079028
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
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产品名称

卡洛芬, ≥97% (HPLC)

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CC(C(O)=O)c1ccc2c(c1)[nH]c3ccc(Cl)cc23

InChI

1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)

InChI key

PUXBGTOOZJQSKH-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

Biochem/physiol Actions

卡洛芬是一种非甾体抗炎药（NSAID），研究发现它具有抗菌活性。 卡洛芬主要用作兽医镇痛药和消炎药，用于关节炎和疼痛。 它的抗炎活性是由于环氧合酶选择性抑制 COX-2 抑制作用，而其抗微生物活性的机制尚不清楚。 卡洛芬可通过渗透枯草芽孢杆菌的膜来杀死它。 其他研究表明，卡洛芬可以靶向大肠杆菌 DNA 聚合酶 III β 亚基。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
086M4735V

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Arundhati Maitra et al.
British medical bulletin, 118(1), 138-148 (2016-05-07)
The number of cases of drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), has risen rapidly in recent years. This has led to the resurgence in repurposing existing drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), for anti-TB treatment. Evidence
Anne Lamsa et al.
ACS chemical biology, 11(8), 2222-2231 (2016-05-20)
Increasing antimicrobial resistance has become a major public health crisis. New antimicrobials with novel mechanisms of action (MOA) are desperately needed. We previously developed a method, bacterial cytological profiling (BCP), which utilizes fluorescence microscopy to rapidly identify the MOA of
Zhou Yin et al.
Chemistry & biology, 21(4), 481-487 (2014-03-19)
Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial properties of the NSAIDs carprofen, bromfenac, and vedaprofen, and show that these NSAIDs inhibit the Escherichia coli DNA polymerase III
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全球贸易项目编号

货号GTIN
SML1713-10MG04061838356963
SML1713-50MG04061832274416