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SML1845

Thapsigargin

Name: Thapsigargin
Brand: SIGMA

From (Thapsia garganica L seeds), ≥98% (HPLC), calcium ion pumps inhibitor, DMSO solution

别名:

CHEBI:9516, CHEMBL96926, MFCD00083511, UNII-Z96BQ26RZD, Z96BQ26RZD, [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

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关于此项目

经验公式（希尔记法）:

C₃₄H₅₀O₁₂

化学文摘社编号:

67526-95-8

分子量:

650.75

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

DMSO solution

Quality level:

200

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属性

产品名称

Thapsigargin Ready Made Solution, ≥98% (HPLC), 10 mM in DMSO

biological source

(Thapsia garganica L seeds)

Quality Level

200

assay

≥98% (HPLC)

form

DMSO solution

concentration

10 mM in DMSO

shipped in

dry ice

storage temp.

−20°C

SMILES string

O1[C@@H]2[C@]([C@H](C[C@@]([C@H]3[C@@H]([C@H](C(=C32)C)OC(=O)\C(=C/C)\C)OC(=O)CCCCCCC)(OC(=O)C)C)OC(=O)CCC)([C@@](C1=O)(O)C)O

InChI

1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1

InChI key

IXFPJGBNCFXKPI-FSIHEZPISA-N

说明

Application

毒胡萝卜素即配型溶液可作为体内生长和体外翻译检测的阴性对照。

Biochem/physiol Actions

毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。钙离子泵的抑制会导致细胞内钙离子水平上升。100nM浓度的毒胡萝卜素可有效抑制心肌和骨骼肌中的SR Ca²⁺ -三磷酸腺苷酶（ATP酶）。毒胡萝卜素还可通过干扰自噬体-溶酶体融合而有效阻断自噬。

毒胡萝卜素是一种有效的钙离子泵抑制剂，位于骨骼肌、心肌、肌肉和脑组织的肌质网（SR）和内质网（ER）微粒体上。

Other Notes

在浓度为10 mM的DMSO中提供了毒胡萝卜素即用型溶液。该溶液可用 DMSO 进一步稀释至 2 mM 浓度。建议将预先制好的毒胡萝卜素溶液小等份保存于-20°C下。

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

历史批次信息供参考:

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Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.

Zhouteng Tao et al.

Human molecular genetics, 24(9), 2426-2441 (2015-01-13)

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are the two common neurodegenerative diseases that have been associated with the GGGGCC·GGCCCC repeat RNA expansion in a noncoding region of C9orf72. It has been previously reported that unconventional repeat-associated non-ATG (RAN)

Drug action of thapsigargin on the Ca2+ pump protein of sarcoplasmic reticulum.

Y Kijima et al.

The Journal of biological chemistry, 266(34), 22912-22918 (1991-12-05)

Thapsigargin is found to be a potent inhibitor of the intracellular Ca2+ pump proteins from skeletal muscle sarcoplasmic reticulum (SR), cardiac SR, and brain microsomes. For skeletal muscle SR, the molar ratio of thapsigargin to Ca2+ pump protein for complete

Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus.

Yuniesky Andrade-Talavera et al.

Cerebral cortex (New York, N.Y. : 1991), 26(8), 3637-3654 (2016-06-11)

Spike timing-dependent plasticity (STDP) is a Hebbian learning rule important for synaptic refinement during development and for learning and memory in the adult. Given the importance of the hippocampus in memory, surprisingly little is known about the mechanisms and functions

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全球贸易项目编号

货号	GTIN
SML1845-4MG	04061832276694