SML1868
鸦胆子苦醇
From Brucia javanica, ≥95% (HPLC), NRF2 inhibitor, powder
别名:
(+)-鸦胆子苦醇, (11β,12α,15β)-13,20-环氧-3,11,12-三羟基-15-[（3-甲基-1-氧代-2-丁烯-1-基）氧]-2,16-二氧代-picras-3-烯-21-酸甲酯, NSC 172924, 鸦胆子苦醇
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关于此项目
经验公式（希尔记法）:
C26H32O11
化学文摘社编号:
分子量:
520.53
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
产品名称
鸦胆子苦醇, ≥95% (HPLC)
biological source
(Brucia javanica)
Quality Level
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D +35 to +44°, c = 0.5 in acetone
storage condition
desiccated
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
CC1=C(O)C(C[C@@]2(C)[C@@]1([H])C[C@]3([H])[C@]45[C@]2([H])[C@@H](O)[C@H](O)[C@](OC5)(C(OC)=O)[C@]4([H])[C@@H](OC(C=C(C)C)=O)C(O3)=O)=O
InChI
1S/C26H32O11/c1-10(2)6-15(28)37-18-20-25-9-35-26(20,23(33)34-5)21(31)17(30)19(25)24(4)8-13(27)16(29)11(3)12(24)7-14(25)36-22(18)32/h6,12,14,17-21,29-31H,7-9H2,1-5H3/t12-,14+,17+,18+,19+,20+,21-,24-,25+,26-/m0/s1
InChI key
ZZZYHIMVKOHVIH-VILODJCFSA-N
Application
鸦胆子苦醇已被用于研究 Nrf2（核因子，红系 2 样 2）在肠缺血/再灌注诱导损伤中的保护作用。
Biochem/physiol Actions
鸦胆子苦醇促进 Nrf2（核因子，红系 2 样 2）泛素化和降解。鸦胆子苦醇上调多种核糖体成分的表达，控制大分子复合物功能。
鸦胆子苦醇是一种植物来源的天然苦木苦味素，在癌症培养物中表现出广泛的细胞毒性（IC 50 <1 μM， 457 个癌细胞系），通过抑制细胞蛋白的从头合成（在 A549 细胞中有效浓度 <50 nM），包括 NRF2
鸦胆子苦醇是一种植物来源的天然苦木苦味素，表现出广泛的细胞毒性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
W Willingham et al.
Biochimica et biophysica acta, 654(2), 169-174 (1981-07-27)
The mechanism by which brusatol inhibits protein synthesis in rabbit reticulocytes has been investigated. When added to reticulocyte lysates, brusatol inhibits endogenous protein synthesis only after a lag of 2-4 min at 30 degrees C. During this period 80 S
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.
Ren V, et al.
Proceedings of the National Academy of Sciences of the USA, 108(4), 201014275-201014275 (2011)
Steffan Vartanian et al.
Molecular & cellular proteomics : MCP, 15(4), 1220-1231 (2015-12-30)
The KEAP1/Nrf2 pathway senses and responds to changes in intracellular oxidative stress. Mutations that result in constitutive activation of Nrf2 are present in several human tumors, especially non-small cell lung cancer. Therefore, compounds that inhibit Nrf2 activity might be beneficial
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1868-25MG | 04061833253953 |
| SML1868-5MG | 04061833253960 |