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SRP0456

BRD3 (306-417) His tag human

Name: BRD3 (306-417) His tag human
Brand: SIGMA

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

别名:

ORFX, RING3L, bromodomain containing 3

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

aqueous solution

Assay:

≥90% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in E. coli

Mol wt:

14.1 kDa

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属性

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

14.1 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_007371

UniProt accession no.

Q15059

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... BRD3(8019)

说明

General description

Human Bromodomain containing 3, also known as BRD3 or RING3L (GenBank Accession No. NM_007371) amino-acids 306 – 417 with N-terminal HIS-tag, MW = 14.1 kDa, expressed in an E. coli expression system.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

3103120207

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Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.

Roland Gamsjaeger et al.

Molecular and cellular biology, 31(13), 2632-2640 (2011-05-11)

Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming clear that

Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

Janine M Lamonica et al.

Proceedings of the National Academy of Sciences of the United States of America, 108(22), E159-E168 (2011-05-04)

Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved

全球贸易项目编号

货号	GTIN
SRP0456-100UG	04061832782645