SRP2081
Retinoblastoma protein human
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
别名:
OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1
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关于此项目
NACRES:
NA.26
UNSPSC Code:
12352202
Form:
frozen liquid
Assay:
≥70% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in insect cells
Mol wt:
~107.5 kDa
biological source
human
recombinant
expressed in insect cells
assay
≥70% (SDS-PAGE)
form
frozen liquid
mol wt
~107.5 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
400 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... RB1(5925)
General description
The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.
Biochem/physiol Actions
pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
W H Lee et al.
Science (New York, N.Y.), 235(4794), 1394-1399 (1987-03-13)
Recent evidence indicates the existence of a genetic locus in chromosome region 13q14 that confers susceptibility to retinoblastoma, a cancer of the eye in children. A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.
S H Friend et al.
Nature, 323(6089), 643-646 (1986-10-16)
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignant cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are recessive
Z Onadim et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(13), 6177-6181 (1992-07-01)
The retinoblastoma-predisposition gene, RB1, segregates as an autosomal dominant trait with high (90%) penetrance. Certain families, however, show an unusual low-penetrance phenotype with many individuals being unaffected, unilaterally affected, or with evidence of spontaneously regressed tumors. We have used single-strand
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SRP2081-5UG | 04061837200229 |