biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
potency
0.1 ng/mL
mol wt
6.0 kDa
packaging
pkg of 500 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
off-white to yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... EGF(13645)
General description
EGF (epidermal growth factor) 是一种强效的生长因子，能刺激多种表皮和上皮细胞的增殖。重组鼠 EGF 是一种 6 kDa 的球状蛋白，含有 53 个氨基酸残基，包括 3 个分子内二硫键。
Application
来自小鼠的 EGF 也用于 DMEM/F12 培养基中培养小鼠肾细胞。
Biochem/physiol Actions
表皮生长因子 (EGF) 具有抑制胃液分泌、促进伤口愈合的作用。 EGF 通过一种称为 c-erbB 的受体传递信号，c-erbB 是一类酪氨酸激酶受体。该受体还与 TGF（转化生长因子）-α和 VGF（牛痘病毒生长因子）结合。EGF 在胚胎发生和心脏发生中起重要角色。
Physical form
从 10 mM 磷酸钠 (pH 8.2) 冻干。
Preparation Note
打开前离心小瓶。用水复溶至 0.5-1.0 mg/mL 浓度。切勿涡旋。该溶液可在 2-8°C 条件下至多储存 1 周。为了延长储存时间，建议在含有载体蛋白（例如 0.1%BSA）的缓冲液中进一步稀释，并在-20°C 至-80°C 下储存。
Other Notes
NSYPGCPSSY DGYCLNGGVC MHIESLDSYT CNCVIGYSGD RCQTRDLRWW ELR
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
商品
可生成组织和干细胞来源3D脑、胃肠道、肺和癌症肿瘤类器官模型的类器官培养产品。
Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.
EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner.
Ma CX
Cellular and Molecular Life Sciences, 72, 2005-2022 (2015)
Requirement of Leukemia Inhibitory Factor or Epidermal Growth Factor for Pre-Implantation Embryogenesis via JAK/STAT3 Signaling Pathways.
Cheng EH
PLoS ONE, 11, e0153086-e0153086 (2016)
Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.
Menezes LF
EBioMedicine, 5, 183-192 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SRP3196-500UG | 04061837211287 |