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SRP5102

Mortalin (47-end), GST tagged human

Name: Mortalin (47-end), GST tagged human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

别名:

CSA, GRP75, HSPA9, HSPA9B, MGC4500, MOT, MOT2, MTHSP75, PBP74, mot-2

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关于此项目

化学文摘社编号:

753517-83-8

NACRES:

NA.32

UNSPSC Code:

12352200

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf9 cells

Mol wt:

~97 kDa

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属性

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~97 kDa

NCBI accession no.

NM_004134

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HSPA9(3313)

说明

General description

Mortalin is a mitochondrial chaperone and a member of the heat shock protein 70 family that is constitutively expressed in cells. Mortalin plays a central role in mitochondrial biogenesis through its capacity to direct the import of nuclear-encoded proteins into the mitochondria. Mortalin plays a role in the control of cell proliferation and elevated levels of mortalin have correlated with malignant transformation and poor cancer prognosis. Mortalin can support cancer cell resistance to complement-dependent cytotoxicity. Mortalin expression was decreased in the mitochondrial fraction of neurons from the substantia nigra of Parkinson disease patients.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

R255-1

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Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.

David Pilzer et al.

International journal of cancer, 126(6), 1428-1435 (2009-09-10)

Mortalin, the mitochondrial hsp70, is a vital constitutively expressed heat shock protein. Its elevated expression has been correlated with malignant transformation and poor cancer prognosis. Cancer cells exhibit increased resistance to complement-dependent cytotoxicity, partly due to their capacity to eliminate

Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease.

Lorena De Mena et al.

Journal of neural transmission (Vienna, Austria : 1996), 116(10), 1289-1293 (2009-08-07)

Mortalin is a mitochondrial chaperone of the heat shock protein 70 family. Mortalin plays a central role in mitochondrial biogenesis through its capacity to direct the import of nuclear-encoded proteins into the mitochondria. As mitochondrial dysfunction has been involved in

全球贸易项目编号

货号	GTIN
SRP5102-50UG	04061832942254