SRP5205
MBP, GST标记 人
recombinant, expressed in E. coli, ≥65% (SDS-PAGE), buffered aqueous glycerol solution
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关于此项目
Form:
buffered aqueous glycerol solution
Assay:
≥65% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~36 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥65% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~36 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MBP(4155)
General description
髓鞘碱性蛋白（MBP）是 CNS（中枢神经系统）髓鞘的重要组成部分，是一种自身免疫原。它定位于人类染色体 18q 上。
Biochem/physiol Actions
MBP 或髓鞘碱性蛋白在髓磷脂形成过程中形成跨胞质的二聚体。涉及折叠、聚合和底物特异性的蛋白质区域在各种物种中均是保守的，并且在髓磷脂膜中的蛋白质-脂质相互作用中可能具有特殊作用。MBP 是多种蛋白激酶的有效底物，与 MARCKS 蛋白具有相似性，均具有受其环境调控的扩展构象、N 末端修饰，与脂质相互作用的双重性质以及与肌动蛋白和 Ca2+-钙调蛋白的结合。髓鞘碱性蛋白（MBP）预期在 MS（多发性硬化症）等脱髓鞘疾病中发挥重要作用。
Physical form
以 50 mM Tris-HCl，pH 7.5，150mM NaCl，10 mM 谷胱甘肽，0.1 mM EDTA，0.25 mM DTT，0.1 mM PMSF，25％ 甘油的形式提供。
Preparation Note
开封后，分装少量，-70℃ 储存。避免重复处理和多次冻融循环
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
G Harauz et al.
Molecular and cellular biochemistry, 209(1-2), 155-163 (2000-08-15)
Myelin basic protein (MBP) and myristoylated alanine-rich C-kinase substrate (MARCKS) are similar in terms of having extended conformations regulated by their environment (i.e., solubilised or lipid-associated), N-terminal modifications, a dual nature of interactions with lipids, binding to actin and Ca2+-calmodulin
Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
Campagnoni AT, et al.
Test, 268(7), 4930-4938 (1993)
Variation within MBP gene predicts disease course in multiple sclerosis
Zhou Y, et al.
Brain and Behavior, 7(4), e00670-e00670 (2017)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SRP5205-50UG | 04061832943015 |