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T0826

叔丁基溴

Name: 叔丁基溴
Brand: SIGMA

≥98% (HPLC), solid

别名:

4,5,6,7-四溴-2-氮杂苯并咪唑, NSC 231634, TBBt, 四溴苯并三唑

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关于此项目

经验公式（希尔记法）:

C₆HN₃Br₄

化学文摘社编号:

17374-26-4

分子量:

434.71

NACRES:

NA.77

PubChem Substance ID:

24724628

UNSPSC Code:

12352200

MDL number:

MFCD06411399

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: 28 mg/mL

storage temp.

2-8°C

SMILES string

Brc1c(Br)c(Br)c2[nH]nnc2c1Br

InChI

1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)

InChI key

OMZYUVOATZSGJY-UHFFFAOYSA-N

说明

Application

TBB 用于研究 DNA 损伤介质蛋白 MDC1 的酪蛋白激酶 2 依赖性磷酸化。

Biochem/physiol Actions

TBB 与酪蛋白激酶-2 的 Val66 残基结合，抑制 ATP/GTP 的结合。TBB 具有细胞渗透性；在 Jurkat 细胞中诱导半胱天冬酶依赖性细胞凋亡并降解造血谱系细胞特异性蛋白 1。

TBB 是酪蛋白激酶-2 (CK2) 的高度选择性 ATP/GTP 竞争性抑制剂（IC ₅₀ = 900 nM 和 1.6 mM，分别使用大鼠肝脏和重组人 CK2）。

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

S Sarno et al.

FEBS letters, 496(1), 44-48 (2001-05-10)

The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP)

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.

Maria Ruzzene et al.

The Biochemical journal, 364(Pt 1), 41-47 (2002-05-04)

Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as judged by several criteria. TBB-promoted apoptosis is preceded by inhibition of Ser/Thr phosphorylation of haematopoietic lineage cell-specific protein 1 (HS1) and

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.

J Ross Chapman et al.

EMBO reports, 9(8), 795-801 (2008-06-28)

Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins

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全球贸易项目编号

货号	GTIN
T0826-10MG	04061837335822