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T0895

胸腺嘧啶

Name: 胸腺嘧啶
Brand: SIGMA

BioReagent, suitable for cell culture

别名:

2,4-二羟基-5-甲基嘧啶, 5-甲基尿嘧啶

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关于此项目

经验公式（希尔记法）:

C₅H₆N₂O₂

化学文摘社编号:

65-71-4

分子量:

126.11

UNSPSC Code:

12352207

NACRES:

NA.75

PubChem Substance ID:

24899920

EC Number:

200-616-1

Beilstein/REAXYS Number:

117880

MDL number:

MFCD00006026

Assay:

≥99% (HPLC)

Biological source:

synthetic

Form:

powder

Solubility:

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faintly yellow

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属性

biological source

synthetic

Quality Level

200

product line

BioReagent

assay

≥99% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

~320 °C (dec.) (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faintly yellow

SMILES string

CC1=CNC(=O)NC1=O

InChI

1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

InChI key

RWQNBRDOKXIBIV-UHFFFAOYSA-N

Gene Information

mouse ... Tymp(72962)

说明

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Triazolyl donor/acceptor chromophore decorated unnatural nucleosides and oligonucleotides with duplex stability comparable to that of a natural adenine/thymine pair.

Subhendu Sekhar Bag et al.

The Journal of organic chemistry, 78(2), 278-291 (2012-11-23)

We report the design and synthesis of triazolyl donor/acceptor unnatural nucleosides via click chemistry and studies on the duplex stabilization of DNA containing two such new nucleosides. The observed duplex stabilization among the self-pair/heteropair has been found to be comparable

Thymine DNA glycosylase.

U Hardeland et al.

Progress in nucleic acid research and molecular biology, 68, 235-253 (2001-09-14)

More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives

7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.

Ibtissam Talhaoui et al.

Nucleic acids research, 41(2), 912-923 (2012-12-05)

Hydroxyl radicals predominantly react with the C(8) of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway.

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全球贸易项目编号

货号	GTIN
T0895-25G	04061837336065
T0895-5G	04061837336072