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Merck
CN

T0938

抗-肿瘤坏死因子-α 山羊抗

affinity isolated antibody, lyophilized powder

别名:

抗-TNF-α

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关于此项目

NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (c), FACS, IF, Neutral, WB
Citations:
45
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biological source

goat

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: suitable, flow cytometry: 5-25 μg/mL, indirect immunofluorescence: 15 μg/mL using mouse cells and tissues, neutralization: suitable, western blot: 0.1-0.2 μg/mL

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Tnf(21926)

General description

肿瘤坏死因子-α(TNF-α)是由脂多糖刺激的巨噬细胞产生的蛋白质,可引起肿瘤坏死。它还促进许多功能,例如刺激人成纤维细胞和其他细胞系的生长,激活多形核中性粒细胞和破骨细胞以及胶原酶的产生。抗肿瘤坏死因子α抗体可用于中和重组小鼠TNF-α的生物学活性。也可用于间接免疫荧光。山羊抗肿瘤坏死因子α抗体与重组小鼠TNF-α特异性反应。

Immunogen

重组小鼠TNF-α

Application

抗肿瘤坏死因子α抗体可用于ELISA捕获和流式细胞术。它还可用于免疫印迹法。

Biochem/physiol Actions

该抗体中和重组小鼠TNF-α的生物学活性。

Physical form

从含有5%海藻糖的磷酸盐缓冲生理盐水的0.2 μm过滤的溶液中冻干。

Preparation Note

使用小鼠TNF-α亲和层析进行纯化。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

低风险生物材料
常规特殊物品

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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E A Carswell et al.
Proceedings of the National Academy of Sciences of the United States of America, 72(9), 3666-3670 (1975-09-01)
In studying "hemorrhagic necrosis" of tumors produced by endotoxin, it was found that the serum of bacillus Calmette--Guerin (BCG)-infected mice treated with endotoxin contains a substance (tumor necrosis factor; TNF) which mimics the tumor necrotic action of endotoxin itself. TNF-positive
D R Bertolini et al.
Nature, 319(6053), 516-518 (1986-02-06)
When leukocytes are exposed to mitogens or antigens in vitro, they release bone-resorbing activity into the culture supernatants which can be detected by bioassay. Like many lymphocyte-monocyte products, this activity has been difficult to purify because of its low abundance
J M Dayer et al.
The Journal of experimental medicine, 162(6), 2163-2168 (1985-12-01)
Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated



全球贸易项目编号

货号GTIN
T0938-.1MG04061832717234