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T1443

TCPOBOP

Name: TCPOBOP
Brand: SIGMA

≥98% (HPLC), CAR agonist, solid

别名:

1,4-双-[2-（3,5-二氯吡啶氧基）] 苯, 3,3′,5,5′-四氯-1,4-双（吡啶氧基）苯

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关于此项目

经验公式（希尔记法）:

C₁₆H₈N₂O₂Cl₄

化学文摘社编号:

76150-91-9

分子量:

402.06

UNSPSC Code:

12352200

PubChem Substance ID:

24278723

NACRES:

NA.77

MDL number:

MFCD00057368

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

产品名称

TCPOBOP, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1

InChI

1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H

InChI key

BAFKRPOFIYPKBQ-UHFFFAOYSA-N

Gene Information

human ... NR1I3(9970)

说明

Application

TCPOBOP 已被用于增强小鼠肝癌细胞中 Mcl-1-斜体启动子的功能。TCPOBOP 也被用于研究组成型雄烷受体 (CAR) 诱导小鼠肝细胞基因表达。

Biochem/physiol Actions

TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。

TCPOBOP 作为 CAR 的剂量依赖性直接激动剂，可增强细胞色素 P450 (CYP) 的核受体 CAR 转活。是苯巴比妥类 CYP 诱导剂中已知最有效的成分。

Features and Benefits

该化合物是细胞凋亡研究的特色产品。点击此处，发现更多特色细胞凋亡产品。如需了解有关生物活性小分子在其他研究领域的更多信息，请访问sigma.com/ discover-bsm。

Preparation Note

TCPOBOP 可溶于 DMSO，浓度大于 10 mg/mL。不溶于水。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.

Nicholas J Lodato et al.

Toxicological sciences : an official journal of the Society of Toxicology, 164(1), 115-128 (2018-04-05)

Activation of the nuclear receptor and transcription factor CAR (Nr1i3) by its specific agonist ligand TCPOBOP (1, 4-bis[2-(3, 5-dichloropyridyloxy)]benzene) dysregulates hundreds of genes in mouse liver and is linked to male-biased hepatocarcinogenesis. To elucidate the genomic organization of CAR-induced gene

Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1.

Albert Braeuning et al.

Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1138-1145 (2009-02-25)

Basal as well as xenobiotic-induced expression of the main enzymes from phase I and phase II of drug metabolism is confined to the perivenous areas of the mammalian liver lobule. Whereas signal transduction pathways that govern xenobiotic-induced expression of these

Polychlorinated biphenyls disrupt hepatic epidermal growth factor receptor signaling.

Josiah E Hardesty et al.

Xenobiotica; the fate of foreign compounds in biological systems, 47(9), 807-820 (2016-07-28)

1. Polychlorinated biphenyls (PCBs) are persistent environmental pollutants that disrupt hepatic xenobiotic and intermediary metabolism, leading to metabolic syndrome and nonalcoholic steatohepatitis (NASH). 2. Since phenobarbital indirectly activates Constitutive Androstane Receptor (CAR) by antagonizing growth factor binding to the epidermal growth factor

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全球贸易项目编号

货号	GTIN
T1443-5MG	04061833067055