T2252
脱铁转铁蛋白 人
≥95% protein basis (biuret)
别名:
人转铁蛋白, 铁传递蛋白
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352202
EC Number:
234-318-8
NACRES:
NA.61
MDL number:
eCl@ss:
34058011
Form:
powder
Assay:
≥95% protein basis (biuret), ≥98% (agarose gel electrophoresis)
Biological source:
human
Mol wt:
76-81 kDa
General description
转铁蛋白是一种双叶糖蛋白，含有一个N端叶和一个N端叶。每个结构域被分为两个子结构域，在子结构域之间的间隙中是金属结合位点。一个转铁蛋白分子可以与两个铁离子结合。脱铁转铁蛋白呈现无铁形式。
Application
人脱铁转铁蛋白已用于杜氏改良Eagle培养基/营养混合物以培养：
- 胰导管腺癌（PDAC）细胞系
- 少突胶质细胞
- 肾近端小管上皮细胞（RPTEC/TERT1）
转铁蛋白可以强烈抑制细菌与生物材料的粘附，包括聚苯乙烯、聚甲基丙烯酸甲酯和硅氧烷。在培养基中，20 ug/ml 可以观察到抑制作用 。
Biochem/physiol Actions
转铁蛋白通过受体介导的内吞作用运输铁。铁转运机制发生在血脑屏障的内皮细胞中。转铁蛋白维持铁稳态，是一种铁相关标记物。重症COVID-19中观察到转铁蛋白水平下降。它可以与铁以外的其他分子结合，因此可以用于靶向药物输送。
Other Notes
非血红素铁转运蛋白。
Disclaimer
供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
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存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
高风险级别生物产品--人源产品
此项目有
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2252-100MG | 04061837341885 |
| T2252-500MG | 04061837341908 |
| T2252-1G | 04061837341892 |
| T2252-5G | 04061837341922 |