T2320
T0901317
≥98%
别名:
N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide
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关于此项目
经验公式（希尔记法）:
C17H12NSO3F9
化学文摘社编号:
分子量:
481.33
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Assay:
≥98%
Quality level:
Quality Level
assay
≥98%
mol wt
481.3
storage temp.
−20°C
SMILES string
OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F
InChI
1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChI key
SGIWFELWJPNFDH-UHFFFAOYSA-N
Gene Information
human ... ABCA1(19), NR1H2(7376), NR1H3(10062)
Application
T0901317应用于LXR激动剂研究，以观察小鼠所有受膳食胆固醇调节的基因的表达。此外，它还用于刺激WT（野生型）和Tg（转基因）小鼠放射性标记的腹腔巨噬细胞，以便进行细胞胆固醇流出测定。
Biochem/physiol Actions
T0901317能通过作用于线粒体代谢来阻止胰岛素的分泌。
LXR激动剂，其治疗导致ABC1基因表达的LXR依赖性上调
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Maxwell KN, et al.
Journal of Lipid Research, 44(11), 2109-2119 (2003)
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
Yamada S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 994-1006 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T2320-10MG | 04061841248552 |
| T2320-5MG | 04061837341977 |